SCIENCE & APPROACH
Beyond Genomics
Targeting Core Lineage Biology
Cancer cells are sustained by core lineage programs—deeply embedded biological pathways that establish and preserve cell identity. In healthy tissue, these programs tightly regulate development and function. In cancer, they are co-opted and reinforced, becoming fundamental drivers of tumor growth, survival, and therapeutic resistance.
Rather than being incidental features of malignancy, these lineage programs create hardwired dependencies that tumors rely on to thrive. Because they operate at the foundation of cellular identity, they represent powerful but historically difficult therapeutic opportunities.
At CORE Biomedicine, we leverage cutting-edge biology to uncover these essential dependencies and translate them into druggable targets. By integrating deep biological insight with precision drug discovery, we aim to develop medicines that selectively disrupt the pathways tumors cannot live without—while sparing normal cells—delivering more durable and meaningful benefit for patients.
Precision Beyond Genomics
Precision medicine often focuses on mutations. We go further:
- Detect essential lineage dependencies that define tumor behavior.
- Validate targets using advanced biological models.
- Design molecules that selectively disrupt tumor lineage survival.
The result: Therapies designed to hit cancer where it cannot easily adapt.
Lineage Therapuetics:
Bringing percision medicine to more patients
Broad patient population,
but no precision
Empirical Medicine 1.0
Chemotherapy
Broad patient population, but no precision
Empirical Medicine 2.0
Immunotherapy
Broad patient population, but less precise
Broad patient population,
but less precise
Precise, but limited
patient population
Precision Medicine 1.0
Genomics-driven therapy
Precise, but limited patient population
Precision Medicine 2.0
Lineage-driven therapy
Precise and broad patient population
Precise and broad
patient population
Drug Discovery Approach
First-in-class target identification and drug discovery
Lineage and Genomics
Lineage Surface Markers
DATA SCIENCE + WET LAB
Omics data mining:
DNA sequencing, RNAseq, methylation, proteomics
Cancer Cell Line Encyclopedia
(CCLE)
High-throughput Screeening
(HTS)
Deep-mecahnism driven assays
DepMap:
Cancer cell dependency mapping
AI data modeling
Disease specific animal models
AI-empowered medicinal chemistry
Drug Discovery Approach
First-in-class target identification and drug discovery
Root Cause
Lineage and Genomics
DATA SCIENCE + WET LAB
Omics data mining:
DNA sequencing, RNAseq, methylation, proteomics
Cancer Cell Line Encyclopedia
(CCLE)
DepMap:
Cancer cell dependency mapping
AI data modeling
End Effect
Lineage Surface Markers
DATA SCIENCE + WET LAB
High-throughput Screeening
(HTS)
Deep-mecahnism driven assays
Disease specific animal models
AI-empowered medicinal chemistry